Herbicides/insecticides are designed to absorb into tissue, be it plant leaf or human skin. Toxic or not they are going to get into your blood stream if you expose yourself to them. Eye tissue, soles of your feet, and palms of your hands are the most "absorbable" tissues of your body. Therefore, eye protection, rubber boots, and rubber gloves. Long clothing washed separately. Enough of anything foreign in your blood stream and your liver/kidneys are going to complain. These are both internal organs you want to keep happy.

Livestock and wildlife are generally smart enough to stay away from the stuff.